A study published in the January edition of the journal Pediatrics examines the effect of domperidone on the nutrient composition of breast milk. Domperidone is a drug that is often prescribed to improve breast milk volume, but there is a lack of evidence on its effects on milk composition. The study authors examined a group of mothers who had experienced lactation failure and who had delivered infants at less than 31 weeks gestation. Mothers were randomly assigned to receive domperidone or a placebo for 14 days. Protein, energy, fat, carbohydrate, sodium, calcium and phosphate levels were measured, in addition to serum prolactin levels and total milk volume. Domperidone did not substantially alter the nutrient composition of the breast milk, while it did increase the volume of milk in the mothers studied.
To access the study online, go to http://pediatrics.aappublications.org/cgi/content/abstract/125/1/e107
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